One fun quest in Act 3 is Slithering Dead. In this quest, you go into dark ruins, fight dangerous enemies, and get a special venom buff.
What does this mean for you? More power! More loot! More fun!
In this easy guide, we will show you:
- How to start the quest and talk to Servi;
- Where to go in the Jungle Ruins and Venom Crypts;
- How to get Corpse-Snake Venom from the Serpent Priestess;
- Which venom reward is best for your character;
- Easy tips to finish fast and avoid mistakes;
- Best venom buff choices for Normal and Cruel Mode.
Let’s get your venom buff and make your character stronger!
Path of Exile 2 Slithering Dead quest | Overview
Slithering Dead is a side quest in Path of Exile 2 (POE 2). You can find it in Act 3 when you visit Ziggurat Camp. The quest starts when you talk to Servi, a guide who needs help. She asks you to explore the Jungle Ruins and enter the Venom Crypts to find a special venom. The quest is not part of the main story, but it gives useful rewards. You must choose one of three venom buffs at the end. The best choice depends on your character build. This guide will help you complete the quest and pick the best reward.
| Category | Details |
| Quest Name | Slithering Dead |
| Game | Path of Exile 2 (POE 2) |
| Quest Type | Side Quest |
| Location | Ziggurat Camp, Act 3 |
| Where to Go | Jungle Ruins → Venom Crypts |
| Quest Giver | Servi |
| Objective | Find Corpse-Snake Venom in Venom Crypts |
| How to Complete | Den of the Serpent Priestess, find the corpse, take the venom, return to Servi |
| Main Challenge | Finding the right quest reward |
| Possible Rewards | Three venom buffs (depends on difficulty) |
| Best Reward Choice | Depends on character class |
| Act 3 Difficulty | Normal & Cruel Mode |
Path of Exile 2 Slithering Dead quest | how to start
To start the Slithering Dead quest in Path of Exile 2, go to Ziggurat Camp in Act 3. There, you will find Servi, an NPC who gives the quest. She asks you to explore Jungle Ruins and enter the Venom Crypts. Your task is to find Corpse-Snake Venom inside the Den of the Serpent Priestess. This quest is optional, but it gives useful venom rewards. You can complete it in Normal Mode and Cruel Mode.
| Step | What to Do? |
| 1. Go to Act 3 | You must reach Act 3 in Path of Exile 2. |
| 2. Find Ziggurat Camp | Look for Ziggurat Camp on your map. |
| 3. Talk to Servi | Servi is the NPC quest giver in the camp. |
| 4. Get the quest | Servi asks you to explore Jungle Ruins. |
| 5. Find Venom Crypts | Search for Venom Crypts inside Jungle Ruins. |
| 6. Enter Venom Crypts | The entrance is easy to miss; check the map. |
| 7. Look for the Den of the Serpent Priestess | This area is randomly placed. Search carefully. |
| 8. Get Corpse-Snake Venom | Find the corpse, click on it, and take the venom. |
| 9. Return to Servi | Go back to Ziggurat Camp and give Servi the venom. |
Path of Exile 2 Slithering Dead quest | Walkthrough
To complete the Slithering Dead quest in Path of Exile 2, go to Jungle Ruins and find Venom Crypts. Inside, search for Den of the Serpent Priestess. The location is random, so explore carefully. Find the corpse, click on it, and take Corpse-Snake Venom. Then, return to Servi at Ziggurat Camp to finish the quest. After that, choose your reward.
Path of Exile 2 Slithering Dead quest | Choosing the best reward
After you complete the Slithering Dead quest in Path of Exile 2, you must choose one of three venom rewards from Servi. The best choice depends on your character class. Venom Draught of Clarity is best for melee builds because it boosts mana regeneration. Venom Draught of the Veil is good for Witch or Sorceress since it protects from elemental damage. Venom Draught of Stone is less useful, but can help if you have problems with stun. If you are in Cruel Mode, the best option is Venom Draught of the Lost, which increases Chaos Resistance.
| Reward Name | Effect | Best For |
| Venom Draught of Clarity | +25% Mana Regeneration | Melee Classes (Monk, Warrior) |
| Venom Draught of the Veil | +30% Elemental Ailment Resistance | Witch, Sorceress (Magic Users) |
| Venom Draught of Stone | +25% Stun Threshold | Some Warrior Builds (Stun Issues) |
| Venom Draught of the Lost | +10% Chaos Resistance (Cruel Mode) | All Classes (Very Strong Choice) |
| Venom Draught of the Sky | +5 to All Attributes (Cruel Mode) | Balanced Builds (Average Choice) |
| Venom Draught of the Marshes | 15% Reduced Slow Effects (Cruel Mode) | Niche Builds (Less Useful) |
Conclusion
The Slithering Dead quest in Path of Exile 2 is a side quest in Act 3. You can start it by talking to Servi in Ziggurat Camp. She will ask you to find Corpse-Snake Venom inside the Venom Crypts. This quest is not part of the main story, but it gives useful rewards.
To complete the quest, go to Jungle Ruins and find the Venom Crypts. Inside, search for the Den of the Serpent Priestess. The location is random, so you must explore carefully. Once inside, find the corpse and take the venom. Then, return to Servi to finish the quest.
At the end of the quest, you must choose a reward. There are three venom buffs, and the best choice depends on your character. Melee fighters should pick Venom Draught of Clarity for better mana regeneration. Magic users should take Venom Draught of the Veil for elemental resistance. Other choices can help with stun resistance or Chaos Resistance in Cruel Mode. Pick the reward that fits your character best.
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Where do I start the Slithering Dead quest?
Go to Ziggurat Camp in Act 3 and talk to Servi. She will give you the quest.
Is this quest part of the main story?
No, it is a side quest. You do not have to do it, but it gives useful rewards.
What do I need to do in this quest?
You must go to the Venom Crypts, find the Den of the Serpent Priestess, take Corpse-Snake Venom, and bring it back to Servi.
How do I find the Venom Crypts?
First, go to Jungle Ruins. Inside, look for the entrance to Venom Crypts. Use the map to help you.
What is the hardest part of this quest?
The Den of the Serpent Priestess is in a random place. You must search carefully.
What rewards do I get for this quest?
You can choose one of three venom buffs. The best one depends on your character build.
Can I do this quest in different game modes?
Yes, you can complete it in both Normal and Cruel Mode.
Can I change my venom reward later?
No, you must choose carefully. You cannot change it after picking.
